E(Z) Depth Potential Position Finder




Calculate the energy minimum of a sequence in standard alpha-helix conformation using the Ez potential.

Enter a sequence in one letter code.


The potential works best for transmembrane sequence that contain polar flanking regions. For sequences that have only hydrophobic residues, turn on the following option to add a term of the helix polar terminal atoms

Allow Download of complete energy landscape.


Reference: Senes A, Chadi DC, Law PB, Walters RF, Nanda V, Degrado WF "E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices.", Journal of Molecular Biology (2007) 366(2), 436-48 [PDF reprint]