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Tucker, M. J., Getahun, Z., Nanda, V., DeGrado, W. F. & Gai, F. (2004). A new method for determining the local environment and orientation of individual side chains of membrane-binding peptides. J Am Chem Soc 126, 5078-9. [pdf]
Slovic, A. M., Kono, H., Lear, J. D., Saven, J. G. & DeGrado, W. F. (2004). Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A 101, 1828-33. [pdf]
Lau, W. L., Ege, D. S., Lear, J. D., Hammer, D. A. & DeGrado, W. F. (2004). Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophys J 86, 272-84. [pdf]
Li, R., Gorelik, R., Nanda, V., Law, P. B., Lear, J. D., DeGrado, W. F. & Bennett, J. S. (2004). Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. J Biol Chem 279, 26666-73. [pdf]
Li, R., Hoess, R. H., Bennett, J. S. & DeGrado, W. F. (2003). Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng 16, 65-72. [pdf]
DeGrado, W. F., Gratkowski, H. & Lear, J. D. (2003). How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci 12, 647-65. [pdf]
Walsh, S. T., Cheng, R. P., Wright, W. W., Alonso, D. O., Daggett, V., Vanderkooi, J. M. & DeGrado, W. F. (2003). The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci 12, 520-31. [pdf]
Papoian, G. A., DeGrado, W. F. & Klein, M. L. (2003). Probing the configurational space of a metalloprotein core: an ab initio molecular dynamics study of Duo Ferro 1 binuclear Zn cofactor. J Am Chem Soc 125, 560-9. [pdf]
Maglio, O., Nastri, F., Pavone, V., Lombardi, A. & DeGrado, W. F. (2003). Preorganization of molecular binding sites in designed diiron proteins. Proc Natl Acad Sci U S A 100, 3772-7. [pdf]
Slovic, A. M., Summa, C. M., Lear, J. D. & DeGrado, W. F. (2003). Computational design of a water-soluble analog of phospholamban. Protein Sci 12, 337-48. [pdf]
DeGrado, W. F., Di Costanzo, L., Geremia, S., Lombardi, A., Pavone, V. & Randaccio, L. (2003). Sliding helix and change of coordination geometry in a model di-MnII protein. Angew Chem Int Ed Engl 42, 417-20. [pdf]
Getahun, Z., Huang, C. Y., Wang, T., De Leon, B., DeGrado, W. F. & Gai, F. (2003). Using nitrile-derivatized amino acids as infrared probes of local environment. J Am Chem Soc 125, 405-11. [pdf]
Li, R., Mitra, N., Gratkowski, H., Vilaire, G., Litvinov, R., Nagasami, C., Weisel, J. W., Lear, J. D., DeGrado, W. F. & Bennett, J. S. (2003). Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations. Science 300, 795-8. [pdf]
Cristian, L., Lear, J. D. & DeGrado, W. F. (2003). Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers. Proc Natl Acad Sci U S A 100, 14772-7. [pdf]
Zhu, Y., Alonso, D. O., Maki, K., Huang, C. Y., Lahr, S. J., Daggett, V., Roder, H., DeGrado, W. F. & Gai, F. (2003). Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A 100, 15486-91. [pdf]
Signarvic, R. S. & DeGrado, W. F. (2003). De novo design of a molecular switch: phosphorylation-dependent association of designed peptides. J Mol Biol 334, 1-12. [pdf]
Calhoun, J. R., Kono, H., Lahr, S., Wang, W., DeGrado, W. F. & Saven, J. G. (2003). Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol 334, 1101-15. [pdf]
Cristian, L., Lear, J. D. & DeGrado, W. F. (2003). Determination of membrane protein stability via thermodynamic coupling of folding to thiol-disulfide interchange. Protein Sci 12, 1732-40. [pdf]
DeGrado, W. F. (2003). Computational biology: Biosensor design. Nature 423, 132-3. [pdf]
Lear, J. D., Gratkowski, H., Adamian, L., Liang, J. & DeGrado, W. F. (2003). Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles. Biochemistry 42, 6400-7. [pdf]
Ghirlanda, G., Lear, J. D., Ogihara, N. L., Eisenberg, D. & DeGrado, W. F. (2002). A hierarchic approach to the design of hexameric helical barrels. J Mol Biol 319, 243-53. [pdf]
Marsh, E. N. & DeGrado, W. F. (2002). Noncovalent self-assembly of a heterotetrameric diiron protein. Proc Natl Acad Sci U S A 99, 5150-4. [pdf]
Huang, C. Y., Getahun, Z., Zhu, Y., Klemke, J. W., DeGrado, W. F. & Gai, F. (2002). Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A 99, 2788-93. [pdf]
Tew, G. N., Liu, D., Chen, B., Doerksen, R. J., Kaplan, J., Carroll, P. J., Klein, M. L. & DeGrado, W. F. (2002). De novo design of biomimetic antimicrobial polymers. Proc Natl Acad Sci U S A 99, 5110-4. [pdf]
Howard, K. P., Lear, J. D. & DeGrado, W. F. (2002). Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci U S A 99, 8568-72. [pdf]
Gratkowski, H., Dai, Q. H., Wand, A. J., DeGrado, W. F. & Lear, J. D. (2002). Cooperativity and specificity of association of a designed transmembrane peptide. Biophys J 83, 1613-9. [pdf]
Huang, C. Y., He, S., DeGrado, W. F., McCafferty, D. G. & Gai, F. (2002). Light-induced helix formation. J Am Chem Soc 124, 12674-5. [pdf]
Li, R., Babu, C. R., Valentine, K., Lear, J. D., Wand, A. J., Bennett, J. S. & DeGrado, W. F. (2002). Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy. Biochemistry 41, 15618-24. [pdf]
Summa, C. M., Rosenblatt, M. M., Hong, J. K., Lear, J. D. & DeGrado, W. F. (2002). Computational de novo design, and characterization of an A(2)B(2) diiron protein. J Mol Biol 321, 923-38. [pdf]
Cheng, R. P. & DeGrado, W. F. (2002). Long-range interactions stabilize the fold of a non-natural oligomer. J Am Chem Soc 124, 11564-5. [pdf]
Tang, Y., Ghirlanda, G., Petka, W. A., Nakajima, T., DeGrado, W. F. & Tirrell, D. A. (2001). Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. Gary Hathaway for performing matrix-assisted laser desorption/ionization analyses. Angew Chem Int Ed Engl 40, 1494-1496. [pdf]
Cheng, R. P. & DeGrado, W. F. (2001). De novo design of a monomeric helical beta-peptide stabilized by electrostatic interactions. J Am Chem Soc 123, 5162-3. [pdf]
Liu, D. & DeGrado, W. F. (2001). De novo design, synthesis, and characterization of antimicrobial beta-peptides. J Am Chem Soc 123, 7553-9. [pdf]
Pasternak, A., Kaplan, J., Lear, J. D. & Degrado, W. F. (2001). Proton and metal ion-dependent assembly of a model diiron protein. Protein Sci 10, 958-69. [pdf]
Walsh, S. T., Sukharev, V. I., Betz, S. F., Vekshin, N. L. & DeGrado, W. F. (2001). Hydrophobic core malleability of a de novo designed three-helix bundle protein. J Mol Biol 305, 361-73. [pdf]
Lear, J. D., Gratkowski, H. & DeGrado, W. F. (2001). De novo design, synthesis and characterization of membrane-active peptides. Biochem Soc Trans 29, 559-64. [pdf]
Gratkowski, H., Lear, J. D. & DeGrado, W. F. (2001). Polar side chains drive the association of model transmembrane peptides. Proc Natl Acad Sci U S A 98, 880-5. [pdf]
Ogihara, N. L., Ghirlanda, G., Bryson, J. W., Gingery, M., DeGrado, W. F. & Eisenberg, D. (2001). Design of three-dimensional domain-swapped dimers and fibrous oligomers. Proc Natl Acad Sci U S A 98, 1404-9. [pdf]
Tang, Y., Ghirlanda, G., Vaidehi, N., Kua, J., Mainz, D. T., Goddard, I. W., DeGrado, W. F. & Tirrell, D. A. (2001). Stabilization of coiled-coil peptide domains by introduction of trifluoroleucine. Biochemistry 40, 2790-6. [pdf]
Walsh, S. T., Lee, A. L., DeGrado, W. F. & Wand, A. J. (2001). Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. Biochemistry 40, 9560-9. [pdf]
Huang, C. Y., Getahun, Z., Wang, T., DeGrado, W. F. & Gai, F. (2001). Time-resolved infrared study of the helix-coil transition using (13)C-labeled helical peptides. J Am Chem Soc 123, 12111-2. [pdf]
Cheng, R. P., Suich, D. J., Cheng, H., Roder, H. & DeGrado, W. F. (2001). Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn. J Am Chem Soc 123, 12710-1. [pdf]
DeGrado, W. F. (2001). Introduction: protein design. Chem Rev 101, 3025-6. [pdf]
North, B., Summa, C. M., Ghirlanda, G. & DeGrado, W. F. (2001). D(n)-symmetrical tertiary templates for the design of tubular proteins. J Mol Biol 311, 1081-90. [pdf]
Cheng, R. P., Gellman, S. H. & DeGrado, W. F. (2001). beta-Peptides: from structure to function. Chem Rev 101, 3219-32. [pdf]
Huang, C. Y., Klemke, J. W., Getahun, Z., DeGrado, W. F. & Gai, F. (2001). Temperature-dependent helix-coil transition of an alanine based peptide. J Am Chem Soc 123, 9235-8. [pdf]
Di Costanzo, L., Wade, H., Geremia, S., Randaccio, L., Pavone, V., DeGrado, W. F. & Lombardi, A. (2001). Toward the de novo design of a catalytically active helix bundle: a substrate-accessible carboxylate-bridged dinuclear metal center. J Am Chem Soc 123, 12749-57. [pdf]
Li, R., Babu, C. R., Lear, J. D., Wand, A. J., Bennett, J. S. & DeGrado, W. F. (2001). Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A 98, 12462-7. [pdf]
Lombardi, A., Summa, C. M., Geremia, S., Randaccio, L., Pavone, V. & DeGrado, W. F. (2000). Inaugural article: retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. Proc Natl Acad Sci U S A 97, 6298-305. [pdf]
Choma, C., Gratkowski, H., Lear, J. D. & DeGrado, W. F. (2000). Asparagine-mediated self-association of a model transmembrane helix. Nat Struct Biol 7, 161-6. [pdf]
O'Neil, K. T., Bach, A. C., 2nd & DeGrado, W. F. (2000). Structural consequences of an amino acid deletion in the B1 domain of protein G. Proteins 41, 323-33. [pdf]
Helluin, O., Chan, C., Vilaire, G., Mousa, S., DeGrado, W. F. & Bennett, J. S. (2000). The activation state of alphavbeta 3 regulates platelet and lymphocyte adhesion to intact and thrombin-cleaved osteopontin. J Biol Chem 275, 18337-43. [pdf]
Hill, R. B. & DeGrado, W. F. (2000). A polar, solvent-exposed residue can be essential for native protein structure. Structure Fold Des 8, 471-9. [pdf]
Dalby, P. A., Hoess, R. H. & DeGrado, W. F. (2000). Evolution of binding affinity in a WW domain probed by phage display. Protein Sci 9, 2366-76. [pdf]
Suich, D. J., Mousa, S. A., Singh, G., Liapakis, G., Reisine, T. & DeGrado, W. F. (2000). Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity. Bioorg Med Chem 8, 2229-41. [pdf]
Salom, D., Hill, B. R., Lear, J. D. & DeGrado, W. F. (2000). pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry 39, 14160-70. [pdf]
Talaga, D. S., Lau, W. L., Roder, H., Tang, J., Jia, Y., DeGrado, W. F. & Hochstrasser, R. M. (2000). Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proc Natl Acad Sci U S A 97, 13021-6. [pdf]
Hill, R. B., Raleigh, D. P., Lombardi, A. & DeGrado, W. F. (2000). De novo design of helical bundles as models for understanding protein folding and function. Acc Chem Res 33, 745-54. [pdf]
Dieckmann, G. R., Lear, J. D., Zhong, Q., Klein, M. L., DeGrado, W. F. & Sharp, K. A. (1999). Exploration of the structural features defining the conduction properties of a synthetic ion channel. Biophys J 76, 618-30. [pdf]
Rockwell, A. L., Rafalski, M., Pitts, W. J., Batt, D. G., Petraitis, J. J., DeGrado, W. F., Mousa, S. & Jadhav, P. K. (1999). Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds. Bioorg Med Chem Lett 9, 937-42. [pdf]
Gandhi, C. S., Shuck, K., Lear, J. D., Dieckmann, G. R., DeGrado, W. F., Lamb, R. A. & Pinto, L. H. (1999). Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein. J Biol Chem 274, 5474-82. [pdf]
Walsh, S. T., Cheng, H., Bryson, J. W., Roder, H. & DeGrado, W. F. (1999). Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A 96, 5486-91. [pdf]
Hamm, P., Lim, M., DeGrado, W. F. & Hochstrasser, R. M. (1999). The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure. Proc Natl Acad Sci U S A 96, 2036-41. [pdf]
Baker, D. & DeGrado, W. F. (1999). Engineering and design. Curr Opin Struct Biol 9, 485-6. [pdf]
DeGrado, W. F., Summa, C. M., Pavone, V., Nastri, F. & Lombardi, A. (1999). De novo design and structural characterization of proteins and metalloproteins. Annu Rev Biochem 68, 779-819. [pdf]
Patterson, W. R., Anderson, D. H., DeGrado, W. F., Cascio, D. & Eisenberg, D. (1999). Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Sci 8, 1410-22. [pdf]
DeGrado, W. F., Schneider, J. P. & Hamuro, Y. (1999). The twists and turns of beta-peptides. J Pept Res 54, 206-17. [pdf]
Summa, C. M., Lombardi, A., Lewis, M. & DeGrado, W. F. (1999). Tertiary templates for the design of diiron proteins. Curr Opin Struct Biol 9, 500-8. [pdf]
Kochendoerfer, G. G., Salom, D., Lear, J. D., Wilk-Orescan, R., Kent, S. B. & DeGrado, W. F. (1999). Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry 38, 11905-13. [pdf]
Bryson, J. W., Desjarlais, J. R., Handel, T. M. & DeGrado, W. F. (1998). From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci 7, 1404-14. [pdf]
Cherney, R. J., Wang, L., Meyer, D. T., Xue, C. B., Wasserman, Z. R., Hardman, K. D., Welch, P. K., Covington, M. B., Copeland, R. A., Arner, E. C., DeGrado, W. F. & Decicco, C. P. (1998). Macrocyclic amino carboxylates as selective MMP-8 inhibitors. J Med Chem 41, 1749-51.
Schneider, J. P., Lombardi, A. & DeGrado, W. F. (1998). Analysis and design of three-stranded coiled coils and three-helix bundles. Fold Des 3, R29-40.
Xue, C. B., He, X., Roderick, J., DeGrado, W. F., Cherney, R. J., Hardman, K. D., Nelson, D. J., Copeland, R. A., Jaffee, B. D. & Decicco, C. P. (1998). Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production. J Med Chem 41, 1745-8.
Dieckmann, G. R., McRorie, D. K., Lear, J. D., Sharp, K. A., DeGrado, W. F. & Pecoraro, V. L. (1998). The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. J Mol Biol 280, 897-912. [pdf]
Ghirlanda, G., Lear, J. D., Lombardi, A. & DeGrado, W. F. (1998). From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin. J Mol Biol 281, 379-91. [pdf]
Xue, C. B., Roderick, J., Mousa, S., Olson, R. E. & DeGrado, W. F. (1998). Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists. Bioorg Med Chem Lett 8, 3499-504. [pdf]
Forrest, L. R., DeGrado, W. F., Dieckmann, G. R. & Sansom, M. S. (1998). Two models of the influenza A M2 channel domain: verification by comparison. Fold Des 3, 443-8.
Betz, S. F., Liebman, P. A. & DeGrado, W. F. (1997). De novo design of native proteins: characterization of proteins intended to fold into antiparallel, rop-like, four-helix bundles. Biochemistry 36, 2450-8. [pdf]
Ogihara, N. L., Weiss, M. S., Degrado, W. F. & Eisenberg, D. (1997). The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies. Protein Sci 6, 80-8. [pdf]
Bennett, J. S., Chan, C., Vilaire, G., Mousa, S. A. & DeGrado, W. F. (1997). Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. J Biol Chem 272, 8137-40. [pdf]
Xue, C. B., Roderick, J., Jackson, S., Rafalski, M., Rockwell, A., Mousa, S., Olson, R. E. & DeGrado, W. F. (1997). Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid. Bioorg Med Chem 5, 693-705. [pdf]
DeGrado, W. F. (1997). Proteins from scratch. Science 278, 80-1.
DeGrado, W. F. & Nilsson, B. O. (1997). Engineering and design Screening, selection and design: standing at the crossroads in three dimensions. Curr Opin Struct Biol 7, 455-6. [pdf]
Pinto, L. H., Dieckmann, G. R., Gandhi, C. S., Papworth, C. G., Braman, J., Shaughnessy, M. A., Lear, J. D., Lamb, R. A. & DeGrado, W. F. (1997). A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A 94, 11301-6. [pdf]
Dieckmann, G. R. & DeGrado, W. F. (1997). Modeling transmembrane helical oligomers. Curr Opin Struct Biol 7, 486-94. [pdf]
Sosnick, T. R., Jackson, S., Wilk, R. R., Englander, S. W. & DeGrado, W. F. (1996). The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins 24, 427-32. [pdf]
Betz, S. F., Raleigh, D. P., DeGrado, W. F., Lovejoy, B., Anderson, D., Ogihara, N. & Eisenberg, D. (1996). Crystallization of a designed peptide from a molten globule ensemble. Fold Des 1, 57-64.
Lombardi, A., Bryson, J. W. & DeGrado, W. F. (1996). De novo design of heterotrimeric coiled coils. Biopolymers 40, 495-504.
Zhou, H. X., Hoess, R. H. & DeGrado, W. F. (1996). In vitro evolution of thermodynamically stable turns. Nat Struct Biol 3, 446-51.
Mousa, S. A., DeGrado, W. F., Mu, D. X., Kapil, R. P., Lucchesi, B. R. & Reilly, T. M. (1996). Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist. Circulation 93, 537-43.
Betz, S. F. & DeGrado, W. F. (1996). Controlling topology and native-like behavior of de novo-designed peptides: design and characterization of antiparallel four-stranded coiled coils. Biochemistry 35, 6955-62. [pdf]
Boice, J. A., Dieckmann, G. R., DeGrado, W. F. & Fairman, R. (1996). Thermodynamic analysis of a designed three-stranded coiled coil. Biochemistry 35, 14480-5. [pdf]
Betz, S. F., Bryson, J. W., Passador, M. C., Brown, R. J., O'Neil, K. T. & DeGrado, W. F. (1996). Expression of de novo designed alpha-helical bundles. Acta Chem Scand 50, 688-96.
DeGrado, W. F. & Sosnick, T. R. (1996). Protein minimization: downsizing through mutation. Proc Natl Acad Sci U S A 93, 5680-1. [pdf]
O'Neil, K. T., Hoess, R. H., Raleigh, D. P. & DeGrado, W. F. (1995). Thermodynamic genetics of the folding of the B1 immunoglobulin-binding domain from streptococcal protein G. Proteins 21, 11-21.
Betz, S. F., Raleigh, D. P., DeGrado, W. F., Lovejoy, B., Anderson, D., Ogihara, N. & Eisenberg, D. (1995). Crystallization of a designed peptide from a molten globule ensemble. Fold Des 1, 57-64.
Bryson, J. W., Betz, S. F., Lu, H. S., Suich, D. J., Zhou, H. X., O'Neil, K. T. & DeGrado, W. F. (1995). Protein design: a hierarchic approach. Science 270, 935-41.
Betz, S. F., Bryson, J. W. & DeGrado, W. F. (1995). Native-like and structurally characterized designed alpha-helical bundles. Curr Opin Struct Biol 5, 457-63. [pdf]
Robertson, D. E., Farid, R. S., Moser, C. C., Urbauer, J. L., Mulholland, S. E., Pidikiti, R., Lear, J. D., Wand, A. J., DeGrado, W. F. & Dutton, P. L. (1994). Design and synthesis of multi-haem proteins. Nature 368, 425-32.
O'Neil, K. T., DeGrado, W. F., Mousa, S. A., Ramachandran, N. & Hoess, R. H. (1994). Identification of recognition sequences of adhesion molecules using phage display technology. Methods Enzymol 245, 370-86.
Kienker, P. K., DeGrado, W. F. & Lear, J. D. (1994). A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel. Proc Natl Acad Sci U S A 91, 4859-63. [pdf]
Farid, R. S., Robertson, D. E., Moser, C. C., Pilloud, D., DeGrado, W. F. & Dutton, P. L. (1994). Design and synthesis of simplified energy-converting proteins. Biochem Soc Trans 22, 689-93.
Lovejoy, B., Choe, S., Cascio, D., McRorie, D. K., DeGrado, W. F. & Eisenberg, D. (1993). Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science 259, 1288-93.
Handel, T. M., Williams, S. A. & DeGrado, W. F. (1993). Metal ion-dependent modulation of the dynamics of a designed protein. Science 261, 879-85.
DeGrado, W. F. (1993). Peptide engineering. Catalytic molten globules. Nature 365, 488-9.
Fairman, R., Beran-Steed, R. K., Anthony-Cahill, S. J., Lear, J. D., Stafford, W. F., 3rd, DeGrado, W. F., Benfield, P. A. & Brenner, S. L. (1993). Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. Proc Natl Acad Sci U S A 90, 10429-33.
Lovejoy, B., Le, T. C., Luthy, R., Cascio, D., O'Neil, K. T., DeGrado, W. F. & Eisenberg, D. (1992). X-ray grade crystals of a designed alpha-helical coiled coil. Protein Sci 1, 956-7.
Anthony-Cahill, S. J., Benfield, P. A., Fairman, R., Wasserman, Z. R., Brenner, S. L., Stafford, W. F., 3rd, Altenbach, C., Hubbell, W. L. & DeGrado, W. F. (1992). Molecular characterization of helix-loop-helix peptides. Science 255, 979-83.
Epand, R. M., Cheetham, J. J., Epand, R. F., Yeagle, P. L., Richardson, C. D., Rockwell, A. & Degrado, W. F. (1992). Peptide models for the membrane destabilizing actions of viral fusion proteins. Biopolymers 32, 309-14.
Chung, L. A., Lear, J. D. & DeGrado, W. F. (1992). Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles. Biochemistry 31, 6608-16.
Lovejoy, B., Akerfeldt, K. S., DeGrado, W. F. & Eisenberg, D. (1992). Crystallization of proton channel peptides. Protein Sci 1, 1073-7.
O'Neil, K. T., Hoess, R. H., Jackson, S. A., Ramachandran, N. S., Mousa, S. A. & DeGrado, W. F. (1992). Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library. Proteins 14, 509-15.
Rao, U., Teeter, M. M., Erickson-Viitanen, S. & DeGrado, W. F. (1992). Calmodulin binding to alpha 1-purothionin: solution binding and modeling of the complex. Proteins 14, 127-38.
O'Neil, K. T., Shuman, J. D., Ampe, C. & DeGrado, W. F. (1991). DNA-induced increase in the alpha-helical content of C/EBP and GCN4. Biochemistry 30, 9030-4.
Rafalski, M., Ortiz, A., Rockwell, A., van Ginkel, L. C., Lear, J. D., DeGrado, W. F. & Wilschut, J. (1991). Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesicles. Biochemistry 30, 10211-20.
O'Neil, K. T. & DeGrado, W. F. (1990). How calmodulin binds its targets: sequence independent recognition of amphiphilic alpha-helices. Trends Biochem Sci 15, 59-64.
DeGrado, W. F. & Lear, J. D. (1990). Conformationally constrained alpha-helical peptide models for protein ion channels. Biopolymers 29, 205-13.
Hill, C. P., Anderson, D. H., Wesson, L., DeGrado, W. F. & Eisenberg, D. (1990). Crystal structure of alpha 1: implications for protein design. Science 249, 543-6.
O'Neil, K. T., Hoess, R. H. & DeGrado, W. F. (1990). Design of DNA-binding peptides based on the leucine zipper motif. Science 249, 774-8.
O'Neil, K. T. & DeGrado, W. F. (1990). A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science 250, 646-51.
Rafalski, M., Lear, J. D. & DeGrado, W. F. (1990). Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41. Biochemistry 29, 7917-22.
O'Neil, K. T. & DeGrado, W. F. (1989). The interaction of calmodulin with fluorescent and photoreactive model peptides: evidence for a short interdomain separation. Proteins 6, 284-93.
DeGrado, W. F., Wasserman, Z. R. & Lear, J. D. (1989). Protein design, a minimalist approach. Science 243, 622-8.
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O'Neil, K. T., Erickson-Viitanen, S. & DeGrado, W. F. (1989). Photolabeling of calmodulin with basic, amphiphilic alpha-helical peptides containing p-benzoylphenylalanine. J Biol Chem 264, 14571-8.
Lear, J. D., Wasserman, Z. R. & DeGrado, W. F. (1988). Synthetic amphiphilic peptide models for protein ion channels. Science 240, 1177-81.
Degrado, W. F. (1988). Design of peptides and proteins. Adv Protein Chem 39, 51-124.
Regan, L. & DeGrado, W. F. (1988). Characterization of a helical protein designed from first principles. Science 241, 976-8.
DeGrado, W. F., Erickson-Viitanen, S., Wolfe, H. R., Jr. & O'Neil, K. T. (1987). Predicted calmodulin-binding sequence in the gamma subunit of phosphorylase b kinase. Proteins 2, 20-33.
DeGrado, W. F., Regan, L. & Ho, S. P. (1987). The design of a four-helix bundle protein. Cold Spring Harb Symp Quant Biol 52, 521-6.
Erickson-Viitanen, S. & DeGrado, W. F. (1987). Recognition and characterization of calmodulin-binding sequences in peptides and proteins. Methods Enzymol 139, 455-78.
O'Neil, K. T., Wolfe, H. R., Jr., Erickson-Viitanen, S. & DeGrado, W. F. (1987). Fluorescence properties of calmodulin-binding peptides reflect alpha-helical periodicity. Science 236, 1454-6.
Lear, J. D. & DeGrado, W. F. (1987). Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2. J Biol Chem 262, 6500-5.
Kauer, J. C., Erickson-Viitanen, S., Wolfe, H. R., Jr. & DeGrado, W. F. (1986). p-Benzoyl-L-phenylalanine, a new photoreactive amino acid. Photolabeling of calmodulin with a synthetic calmodulin-binding peptide. J Biol Chem 261, 10695-700.
Cheng, Y. S., Becker-Manley, M. F., Nguyen, T. D., DeGrado, W. F. & Jonak, G. J. (1986). Nonidentical induction of the guanylate binding protein and the 56K protein by type I and type II interferons. J Interferon Res 6, 417-27.
Eisenberg, D., Wilcox, W., Eshita, S. M., Pryciak, P. M., Ho, S. P. & DeGrado, W. F. (1986). The design, synthesis, and crystallization of an alpha-helical peptide. Proteins 1, 16-22.
Cox, J. A., Comte, M., Fitton, J. E. & DeGrado, W. F. (1985). The interaction of calmodulin with amphiphilic peptides. J Biol Chem 260, 2527-34.
DeGrado, W. F., Prendergast, F. G., Wolfe, H. R., Jr. & Cox, J. A. (1985). The design, synthesis, and characterization of tight-binding inhibitors of calmodulin. J Cell Biochem 29, 83-93.
O'Neil, K. T. & DeGrado, W. F. (1985). A predicted structure of calmodulin suggests an electrostatic basis for its function. Proc Natl Acad Sci U S A 82, 4954-8. [pdf]
Briggs, M. S., Gierasch, L. M., Zlotnick, A., Lear, J. D. & DeGrado, W. F. (1985). In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides. Science 228, 1096-9.
Sigal, I. S., DeGrado, W. F., Thomas, B. J. & Petteway, S. R., Jr. (1984). Purification and properties of thiol beta-lactamase. A mutant of pBR322 beta-lactamase in which the active site serine has been replaced with cysteine. J Biol Chem 259, 5327-32.
Chow, T. P., DeGrado, W. F. & Knight, E., Jr. (1984). Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies. J Biol Chem 259, 12220-5.
Robb, R. J., Kutny, R. M., Panico, M., Morris, H., DeGrado, W. F. & Chowdhry, V. (1983). Posttranslational modification of human T-cell growth factor. Biochem Biophys Res Commun 116, 1049-55.
DeGrado, W. F., Musso, G. F., Lieber, M., Kaiser, E. T. & Kezdy, F. J. (1982). Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophys J 37, 329-38.
DeGrado, W. F., Wasserman, Z. R. & Chowdhry, V. (1982). Sequence and structural homologies among type I and type II interferons. Nature 300, 379-81.