E(Z) Depth Potential Position Finder




Calculate the energy minimum of a sequence in standard alpha-helix conformation using the Ez potential.

Enter a sequence in one letter code.

Or Upload a PDB File.


The potential works best for transmembrane sequence that contain polar flanking regions. For sequences that have only hydrophobic residues, turn on the following option to add a term of the helix polar terminal atoms

Allow Download of complete energy landscape.


Reference: Senes A, Chadi DC, Law PB, Walters RF, Nanda V, Degrado WF "E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices.", Journal of Molecular Biology (2007) 366(2), 436-48 [PDF reprint]

Contact comp at degrado dot med dot upenn dot edu with general feedback/bug reports/requests.